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Grande-Allen Integrative Matrix Mechanics Lab


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  • Stephens EH, Han J, Trawick EA, Di Martino ES, Akkiraju H, Brown LM, Connell JP, Grande-Allen KJ, Vunjak-Novakovic G, Takayama H. Left-Ventricular Assist Device Impact on Aortic Valve Mechanics, Proteomics and Ultrastructure. Ann Thorac Surg. 105(2):572-580, 2018.


  • Vukicevic M, Puperi DS, Grande-Allen KJ, Little SH. 3D printed modeling of the mitral valve for catheter-based structural interventions.Ann Biomed Eng. 45 (2), 508-519, 2017.
  • Dasi LP, Grande-Allen J, Kunzelman K, Kuhl E. The Pursuit of Engineering the Ideal Heart Valve Replacement or Repair: A Special Issue of the Annals of Biomedical Engineering. Ann Biomed Eng. 45(2):307-309, 2017.
  • Peng DH, Ungewiss C, Tong P, Byers LA, Wang J, Canales JR, Villalobos PA, Uraoka N, Mino B, Behrens C, Wistuba II, Han RI, Wanna CA, Fahrenholtz M, Grande-Allen KJ, Creighton CJ, Gibbons DL. ZEB1 induces LOXL2-mediated collagen stabilization and deposition in the extracellular matrix to drive lung cancer invasion and metastasis. Oncogene, 36(14):1925-1938, 2017.
  • Krishnamurthy VK, Stout AJ, Sapp MC, Matuska B, Lauer ME, Grande-Allen KJ. Dysregulation of hyaluronan homeostasis during aortic valve disease. Matrix Biology. 62:40-57, 2017.
  • Grande‐Allen KJ, Puperi D, Ravishankar P, Balachandran K. Aortic Valve Mechanobiology. Mechanobiology: Exploitation for Medical Benefit, p. 191-205, 2017.
  • Wu Y, Puperi DS, Grande-Allen KJ, West JL. Ascorbic acid promotes extracellular matrix deposition while preserving valve interstitial cell quiescence within 3D hydrogel scaffolds. J Tissue Eng Regen Med. 11(7):1963-1973, 2017.


  • MC Sapp MC, Krishnamurthy VK, Puperi DS, Bhatnagar S, Fatora G, Mutyala N, Grande-Allen KJ. Differential cell-matrix responses in hypoxia-stimulated aortic versus mitral valves. J R Soc Interface, 13(125):20160449, 2016.
  • Puperi DS, Kishan A, Punske ZE, Wu Y, Cosgriff-Hernandez E, West JL, Grande-Allen, KJ. Electrospun polyurethane and hydrogel composite scaffolds as biomechanical mimics for aortic valve tissue engineering. ACS Biomaterials Science & Engineering, 2(9):1546-1558, 2016.
  • Wu Y, Grande-Allen KJ, West JL. Adhesive Peptide Sequences Regulate Valve Interstitial Cell Adhesion, Phenotype and Extracellular Matrix Deposition. CMBE, 9(4):479-495, 2016.
  • Blancas AA, Balaoing LR, Acosta FM, Grande-Allen KJ.Identifying Behavioral Phenotypes and Heterogeneity in Heart Valve Surface Endothelium. Cells Tissues Organs201(4):268-76, 2016.
  • Puperi DS, O’Connell RW, Punske ZE, Wu Y, West JL, Grande-Allen KJ. Hyaluronan Hydrogels for a Biomimetic Spongiosa Layer of Tissue Engineered Heart Valve Scaffolds. Biomacromolecules. 17(5):1766-75, 2016.
  • Arevalos CA, Berg JM, Nguyen JM, Godfrey EL, Iriondo C, Grande-Allen KJ. Valve Interstitial Cells Act in a Pericyte Manner Promoting Angiogensis and Invasion by Valve Endothelial Cells. Ann Biomed Eng. 44(9):2707-23, 2016.
  • Han RI, Wheeler TM, Lumsden AB, Reardon MJ, Lawrie GM, Grande-Allen KJ, Morrisett JD, Brunner G. Morphometric analysis of calcification and fibrous layer thickness in carotid endarterectomy tissues. Comput Biol Med. 70:210-219, 2016.
  • Pankova D, Chen Y, Terajima M, Schliekelman MJ, Baird BN, Fahrenholtz M, Sun L, Gill BJ, Vadakkan TJ, Kim MP, Ahn YH, Roybal JD, Liu X, Parra Cuentas ER, Rodriguez J, Wistuba II, Creighton CJ, Gibbons DL, Hicks JM, Dickinson ME, West JL, Grande-Allen KJ, Hanash SM, Yamauchi M, Kurie JM. Cancer-Associated Fibroblasts Induce a Collagen Cross-link Switch in Tumor Stroma. Mol Cancer Res. 2016. 14(3):287-95.
  • Connell PS, Azimuddin AF, Kim SE, Ramirez F, Jackson MS, Little SH, Grande-Allen KJ. Regurgitation Hemodynamics Alone Cause Mitral Valve Remodeling Characteristic of Clinical Disease States In Vitro. Ann Biomed Eng. 44(4):954-67, 2016.
  • Scully BB, Fan C, Grigoryan B, Jacot JG, Vick GW 3rd, Kim JJ, Fraser CD Jr, Grande-Allen KJ, Morales DL. Remodeling of ECM patch into functional myocardium in an ovine model: A pilot study. J Biomed Mater Res B Appl Biomater.104(8):1713-1720, 2016.
  • Stephens EH, Nguyen TC, Blazejewski JG, Vekilov DP, Connell JP, Itoh A, Ingels NB Jr, Miller DC, Grande-Allen KJ. Extracellular matrix remodeling in wound healing of critical size defects in the mitral valve leaflet. Heart Vessels, 31(7):1186-95, 2016.


  • Fahrenholtz MM, Wen S, Grande-Allen KJ. Development of a heart valve model surface for optimization of surface modifications. Acta Biomater, 26:64-71, 2015.
  • Puperi DS, Balaoing LR, O’Connell RW, West JL, Grande-Allen KJ. 3-Dimensional spatially organized PEG-based hydrogels for an aortic valve co-culture model. Biomaterials, 67:354-64, 2015.
  • Stephens EH, Connell PS, Fahrenholtz MM, Timek TA, Daughters GT, Kuo JJ, Patton AM, Ingels NB, Miller DC, Grande-Allen KJ. Heterogeneity of Mitral Leaflet Matrix Composition and Turnover Correlates with Regional Leaflet Strain. Cardiovasc Eng Technol, 6(2):141-50, 2015.
  • Stephens EH, Fahrenholtz MM, Connell PS, Timek TA, Daughters GT, Kuo JJ, Patton AM, Ingels NB Jr, Miller DC, Grande-Allen KJ. Cellular and Extracellular Matrix Basis for Heterogeneity in Mitral Annular Contraction.  Cardiovasc Eng Technol, 6(2):151-9, 2015.
  • Balaoing LR, Post AD, Lin AY, Tseng H, Moake JL, Grande-Allen KJ. Laminin Peptide-Immobilized Hydrogels Modulate Valve Endothelial Cell Hemostatic Regulation. PLoS One,. 10(6):e0130749, 2015.
  • Zhang X, Xu B, Puperi DS, Wu Y, West JL, Grande-Allen KJ. Application of hydrogels in heart valve tissue engineering. J Long Term Eff Med Implants. 25(1-2):105-34, 2015.
  • Chen Y, Terajima M, Yang Y, Sun L, Ahn YH, Pankova D, Puperi DS, Watanabe T, Kim MP, Blackmon SH, Rodriguez J, Liu H, Behrens C, Wistuba II, Minelli R, Scott KL, Sanchez-Adams J, Guilak F, Pati D, Thilaganathan N, Burns AR, Creighton CJ, Martinez ED, Zal T, Grande-Allen KJ, Yamauchi M, Kurie JM. Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma. J Clin Invest. 125(3):1147-62, 2015.
  • Arevalos CA, Walborn AT, Rupert AA, Berg JM, Godfrey EL, Nguyen JM, Grande-Allen KJ. Regulation of valve endothelial cell vasculogenic network architectures with ROCK and Rac inhibitors. Microvasc Res. 2015. 98:108-18.
  • Wong FF, Ho ML, Yamagami M, Lam MT, Grande-Allen KJ, Suh J. Effective Gene Delivery to Valvular Interstitial Cells Using Adeno-Associated Virus Serotypes 2 and 3. Tissue Eng Part C Methods. 21(8):808-15, 2015.
  • Kheradvar A, Groves EM, Dasi LP, Alavi SH, Tranquillo R, Grande-Allen KJ, Simmons CA, Griffith B, Falahatpisheh A, Goergen CJ, Mofrad MR, Baaijens F, Little SH, Canic S. Emerging trends in heart valve engineering: Part I. Solutions for future. Ann Biomed Eng. 43(4):833-43, 2015.
  • Kheradvar A, Groves EM, Goergen CJ, Alavi SH, Tranquillo R, Simmons CA, Dasi LP, Grande-Allen KJ, Mofrad MR, Falahatpisheh A, Griffith B, Baaijens F, Little SH, Canic S. Emerging trends in heart valve engineering: Part II. Novel and standard technologies for aortic valve replacement. Ann Biomed Eng. 43(4):844-57, 2015.
  • Kheradvar A, Groves EM, Simmons CA, Griffith B, Alavi SH, Tranquillo R, Dasi LP, Falahatpisheh A, Grande-Allen KJ, Goergen CJ, Mofrad MR, Baaijens F, Canic S, Little SH. Emerging Trends in Heart Valve Engineering: Part III. Novel Technologies for Mitral Valve Repair and Replacement. Ann. Biomed Eng. 43(4):858-70, 2015.
  • Sapp MC, Fares HJ, Estrada AC, Grande-Allen KJ. Multilayer three-dimensional filter paper constructs for the culture and analysis of aortic valvular interstitial cells. Acta Biomater. 13:199-206, 2015.
  • Zhang X, Xu B, Puperi DS, Yonezawa AL, Wu Y, Tseng H, Cuchiara ML, West JL, Grande-Allen KJ. Integrating valve-inspired design features into poly(ethylene glycol) hydrogel scaffolds for heart valve tissue engineering. Acta Biomater. 14:11-21, 2015.


  • Wiltz DC, Han RI, Wilson RL, Kumar A, Morrisett JD, Grande-Allen KJ.Differential Aortic and Mitral Valve Interstitial Cell Mineralization and the Induction of Mineralization by Lysophosphatidylcholine In Vitro. Cardiovasc Eng Technol. 5(4):371-383, 2014.
  • Kamel PI, Qu X, Geiszler AM, Nagrath D, Harmancey R, Taegtmeyer H, Grande-Allen KJ. Metabolic regulation of collagen gel contraction by porcine aortic valvular interstitial cells. J R Soc Interface. 11(101):20140852, 2014.
  • Tseng H, Puperi DS, Kim EJ, Ayoub S, Shah JV, Cuchiara ML, West JL, Grande-Allen KJ. Anisotropic Poly(Ethylene Glycol)/Polycaprolactone Hydrogel-Fiber Composites for Heart Valve Tissue Engineering. Tissue Eng. Part A. 20(19-20):2634-45, 2014.
  • Balaoing LR, Post AD, Minn K, Grande-Allen KJ. Age-related changes in aortic valve hemostatic regulation. Arteriosclerosis, Thrombosis, and Vascular Biology, 34(1):72-80, 2014.
  • Tseng H*, Balaoing LR*, Grigoryan B, Raphael RM, Killian TC, Souza GR, Grande-Allen KJ: A three-dimensional co-culture model of the aortic valve using magnetic levitation. Acta Biomaterialia, 10(1):173-82, 2014.


  • Tseng H, Gage JA, Raphael RM, Moore RH, Killian TC, Grande-Allen KJ, Souza GR. Assembly of a three-dimensional multitype bronchiole co-culture model using magnetic levitation. Tissue Eng Part C Methods, 19(9):665-75, 2013.
  • Tseng H, Kim EJ, Connell PS, Ayoub S, Shah JV, Grande-Allen KJ. The tensile and viscoelastic properties of aortic valve leaflets treated with a hyaluronidase gradient. Cardiovasc Eng Technol, 4(2):151-60, 2013.
  • Gheewala N, Schwarz KA, Grande-Allen KJ. Organ culture of porcine mitral valves as a novel experimental paradigm. Cardiovasc Eng Technol, 4(2):139-50, 2013.
  • Osman N, Grande-Allen KJ, Ballinger ML, Getachew R, Marasco S, O’Brien KD, Little PJ. Smad2-dependent glycosaminoglycan elongation in aortic valve interstitial cells enhances binding of LDL to proteoglycans. Cardiovasc Pathol, 22(2):146-55, 2013.
  • Kumar A, Wiltz DC, Grande-Allen KJ. Gentamicin reduces calcific nodule formation by aortic valve interstitial cells in vitro. Cardiovasc Eng Technol, 4(1):16-25, 2013.
  • Tseng H, Cuchiara ML, Durst CA, Cuchiara MP, Lin CJ, West JL, Grande-Allen KJ. Fabrication and mechanical evaluation of anatomically-inspired quasilaminate hydrogel structures with layer-specific formulations. Ann Biomed Eng, 41(2):398-407, 2013.


  • Stephens EH, Saltarrelli Jr JG, Balaoing LR, Baggett LS, Nandi I, Anderson KM, Morrisett JD, Reardon MJ, Simpson MA, Weigel PH, Olmsted-Davis EA, Davis AR, Grande-Allen KJ. Hyaluronan turnover and hypoxic brown adipocytic differentiation are co-localized with ossification in calcified human aortic valves. Pathol Res Pract, 2012, 208(11):642-50, 2012.
  • Stephens EH, Kearney DL, Grande-Allen KJ. Insight into pathologic abnormalities in congenital semilunar valve disease based on advances in understanding normal valve microstructure and extracellular matrix. Cardiovasc Pathol, 21(1):46-58, 2012.
  • Connell PS, Han RI, Grande-Allen KJ. Differentiating the aging of the mitral valve from human and canine myxomatous degeneration. J Vet Cardiol, 14(1):31-45, 2012.
  • DC Wiltz, CA Arevalos, LR Balaoing, AA Blancas, M Sapp, X Zhang, KJ Grande-Allen. Extracellular matrix organization, structure, and function. E. Aikawa (Ed.). Calcific Aortic Valve Disease. ISBN 980-953-307-820-0. InTECH. 2012.


  • Rajamannan NM, Evans FJ, Aikawa E, Grande-Allen KJ, Demer LL, Heistad DD, Simmons CA, Masters KS, Mathieu P, O’Brien KD, Schoen FJ, Towler DA, Yoganathan AP, Otto CM. Calcific aortic valve disease: not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: Calcific aortic valve disease-2011 update. Circulation, 124(16):1783-91, 2011.
  • Stephens EH, Saltarrelli JG, Baggett LS, Nandi I, Kuo JJ, Davis AR, Olmsted-Davis EA, Reardon MJ, Morrisett JD, Grande-Allen KJ. Differential proteoglycan and hyaluronan distribution in calcified aortic valves. Cardiovasc Pathol, 20(6):334-42, 2011.
  • Durst CA, Cuchiara MP, Mansfield EG, West JL, Grande-Allen KJ. Flexural characterization of cell encapsulated PEGDA hydrogels with applications for tissue engineered heart valves. Acta Biomater, 7(6):2467-76, 2011.
  • Haldar S, Gheewala N, Grande-Allen KJ, Sutton MA, Bruck HA. Multi-scale mechanical characterization of palmetto wood using digital image correlation to develop a template for biologically-inspired polymer composites. Exp Mech, 51(4):575-89, 2011.
  • Tseng H, Grande-Allen KJ. Elastic fibers in the aortic valve spongiosa: A fresh perspective on its structure and role in overall tissue function. Acta Biomater, 7(5):2101-8, 2011.
  • Grande-Allen KJ, Liao J. The heterogeneous biomechanics and mechanobiology of the mitral valve: implications for tissue engineering. Curr Cardiol Rep, 13(2):113-20, 2011.
  • Qu X, Jimenez-Vergara AC, Munoz-Pinto DJ, Ortiz D, McMahon RE, Cristancho D, Becerra-Bayona S, Guiza-Arguello V, Grande-Allen KJ, Hahn MS. Regulation of smooth muscle cell phenotype by glycosaminoglycan identity. Acta Biomater, 7(3):1031-9, 2011.
  • Stephens EH, Durst CA, West JL, Grande-Allen KJ. Mitral valvular interstitial cell responses to substrate stiffness depend on age and anatomic region. Acta Biomater, 7(1):75-82, 2011.


  • Stephens EH, Shangkuan J, Kuo JJ, Carroll JL, Kearney DL, Carberry KE, Fraser CD Jr, Grande-Allen KJ: Extracellular matrix remodeling and cell phenotypic changes in dysplastic and hemodynamically altered semilunar cardiac valves.Cardiovasc Pathol, 20(5):e157-67, 2010.
  • Xu S, Grande-Allen KJ: The evolution of the field of biomechanics through the lens of Experimental Mechanics. Exp Mech, 6(1):2-7, 2010.
  • Gheewala N, Grande-Allen KJ: Design and mechanical evaluation of a physiological mitral valve organ culture system, Cardiovasc Eng Technol, 1(2):123-131, 2010.
  • Stephens EH, Post AD, Laucirica DR, Grande-Allen KJ: Perinatal changes in mitral and aortic valve structure and composition. Ped Dev Pathol, 13(6):447-58, 2010.
  • Liao J, Guo X, Grande-Allen KJ, Kasper FK, Mikos AG. Bioactive polymer/extracellular matrix scaffolds fabricated with a flow perfusion bioreactor for cartilage tissue engineering. Biomaterials, 31(34):8911-20, 2010.
  • Barzilla JE, McKenney AS. Durst CA, Cowan AE, Grande-Allen KJ: Design and validation of a novel splashing bioreactor system for use in mitral valve organ culture. Ann Biomed Eng, 38(11):3280-94, 2010.
  • Barzilla JE, Acevedo FE, Grande-Allen KJ: Organ culture as a tool to identify early mechanisms of serotonergic valve disease. J Heart Valve Dis, 19(5):626-35, 2010.
  • Stephens EH, Carroll JL, Post AD, Kuo JJ, Grande-Allen KJ: Functional characterization of fibronectin-separated valve interstitial cell subpopulations in 3D culture, J Heart Valve Dis, 19(6):759-65, 2010.
  • Durst CA, Grande-Allen KJ: Design and physical characterization of a synchronous multivalve aortic valve culture system. Ann Biomed Eng, 38(2):319-325, 2010.
  • Xu S, Grande-Allen KJ: The role of cell biology and leaflet remodeling in the progression of heart valve disease. Methodist DeBakey Cardiovascular Journal, 6(1):2-7, 2010.
  • Ferdous Z, Peterson SB, Tseng H, Anderson DK, Iozzo RV, Grande-Allen KJ: A role for decorin in controlling proliferation, adhesion, and migration of murine embryonic fibroblasts. J Biomed Mater Res Part A, 93(2):419-428, 2010.
  • Stephens EH, de Jonge N, McNeill MP, Durst CA, Grande-Allen KJ: Age-related changes in material behavior of porcine mitral and aortic valves and correlation to matrix composition. Tissue Eng A, 16(3):867-78, 2010.
  • Stephens EH, Huynh TN, Cieluch JD, Grande-Allen KJ: Fibronectin-based isolation of valve interstitial cell subpopulations: relevance to valve disease. J Biomed Mater Res Part A, 92(1):340-9, 2010.
  • Tseng H, Grande-Allen KJ: Microstructure of the aortic valve: implications for valvular mechanics and function. Advances in Cardiovascular Research, Volume 1, Nova Science Publishers, Inc.: Hauppauge, NY, 2010.


  • Stephens EH, Timek TA, Daughters GT, Kuo JJ, Patton AM, Baggett LS, Ingels NB, Miller DC, Grande-Allen KJ: Significant changes in mitral valve leaflet matrix composition and turnover with tachycardia-induced cardiomyopathy. Circulation 120(11 Suppl):S112-S119, 2009.
  • Allison DD, Braun KR, Wight TN, Grande-Allen KJ: Differential effects of exogenous and endogenous hyaluronan on contraction and strength of collagen gels. Acta Biomater, 5(4):1019-1026, 2009.
  • Gupta V, Barzilla JE, Mendez JS, Stephens EH, Lee EL, Collard CD, Laucirica R, Weigel PH, Grande-Allen KJ: Abundance and location of proteoglycans and hyaluronan within normal and myxomatous mitral valves. Cardiovasc Pathol, 18(4):191-197, 2009.
  • Gupta V, Tseng H, Lawrence BD, Grande-Allen KJ: Effect of cyclic mechanical strain on glycosaminoglycan and proteoglycan synthesis by heart valve cells. Acta Biomater, 5(2):531–540, 2009.


  • Stephens EH, Nguyen TC, Itoh A, Ingels Jr NB, Miller DC, Grande-Allen KJ: The effects of mitral regurgitation alone are sufficient for leaflet remodeling. Circulation 118(14 Suppl):S243-S249, 2008.
  • Ofek G, Revell CM, Hu JC, Allison DD, Grande-Allen KJ, Athanasiou KA: Matrix development in self-assembly of articular cartilage. PLoS ONE, 3(7):e2795, 2008.
  • Stephens ES, Chu CK, Grande-Allen KJ: Valve proteoglycan content and glycosaminoglycan fine structure are unique to microstructure, mechanical loads, and age: relevance to an age-specific tissue engineered heart valve. Acta Biomater, 4(5):1148-1160, 2008.
  • Hahn MS, Jao CY, Faquin W, Grande-Allen KJ: Glycosaminoglycan composition of the vocal fold lamina propria in relation to function. Ann Otol Rhinol Laryngol, 117(5):371-81, 2008.
  • Gupta V, Werdenberg JA, Lawrence BD, Stephens EH, Mendez JS, Grande-Allen KJ: Reversible secretion of glycosaminoglycans and proteoglycans by cyclically stretched valvular interstitial cells in 3D culture. Ann Biomed Eng, 36(7):1092-103, 2008.
  • Allison DD, Wight TN, Ripp NJ, Braun KR, Grande-Allen KJ: Endogenous overexpression of hyaluronan synthases within dynamically cultured collagen gels: implications for vascular and valvular disease. Biomaterials, 29(20):2969–2976, 2008.
  • Xu S, Grande-Allen KJ: Miniaturized collagen static tension tissue molds tested with cardiac aortic valve cells and decorin knocked-out fibroblasts, J Young Investigators, 8(4), 2008 [online].
  • Ferdous Z, Lazaro LD, Iozzo RV, Höök M, Grande-Allen KJ: Influence of cyclic strain and decorin deficiency on 3-D cellularized collagen matrices. Biomaterials, 29(18):2740-8, 2008.
  • Saraf A, Hacker MC, Sitharaman B, Grande-Allen KJ, Barry MA, Mikos AG: Synthesis and conformational evaluation of a novel gene delivery vector for human mesenchymal stem cells. Biomacromolecules, 9(3):818-827, 2008.
  • Nistri S, Grande-Allen KJ, Noale M, Basso C, Maggi S, Thiene G: Aortic elasticity and size in bicuspid aortic valve syndrome, Eur Heart J, 29(4):472-9, 2008.
  • Blevins TL, Peterson SB, Lee EL, Bailey A, Frederick JD, Gupta V, Grande-Allen KJ: Mitral valvular interstitial cells demonstrate regional, adhesional, and synthetic heterogeneity. Cells Tissues Organs, 187(2):113-122, 2008.
  • Gupta V, Werdenberg JA, Mendez JS, Grande-Allen KJ: Influence of strain on proteoglycan synthesis by valvular interstitial cells in 3D culture. Acta Biomater, 4(1):88-96, 2008.


  • Ferdous Z, Wei VM, Iozzo RV, Höök M, Grande-Allen KJ: Decorin-TGF-beta interaction regulates matrix organization and mechanical characteristics of 3-D collagen matrices. J Biol Chem, 282(49):35887-98, 2007.
  • Allison DD, Braun KR, Vasco N, Wight TN, Grande-Allen KJ: The effect of endogenous overexpression of hyaluronan synthases on material, morphological and biochemical properties of uncrosslinked collagen biomaterials. Biomaterials, 28:5509-5517, 2007.
  • Stephens ES, Grande-Allen KJ: Age-related changes in collagen synthesis and turnover in porcine heart valves. J Heart Valve Dis, 16(6):672-682, 2007.
  • Grande-Allen KJ, Osman N, Ballinger ML, Dadlani H, Marasco S, Little PJ: Glycosaminoglycan synthesis and structure as targets for the prevention of calcific aortic valve disease. Cardiovasc Res, 76(1):19-28, 2007.
  • Ferdous Z., Grande-Allen KJ: Utility and control of proteoglycans in tissue engineering. Tissue Eng, 13(8):1893-904, 2007.
  • Stephens ES, Carroll JL, Grande-Allen KJ: The use of collagenase III for the isolation of porcine aortic valvular interstitial cells: rationale and optimization. J Heart Valve Dis, 16(2):175-183, 2007.
  • Gupta V, Werdenberg J, Blevins TL, Grande-Allen KJ: Synthesis of glycosaminoglycans in differently loaded regions of collagen gels seeded with valvular interstitial cells. Tissue Eng, 13(1):41-49, 2007.


  • Blevins TL, Carroll JL, Raza A, Grande-Allen KJ: Phenotypic characterization of isolated valvular interstitial cell subpopulations. J Heart Valve Dis, 15(6):815-822, 2006.
  • Gupta V, Grande-Allen KJ: Effects of static and cyclic loading in regulating extracellular matrix synthesis by cardiovascular cells. Cardiovasc Res, 72(3):375-383, 2006.
  • Barzilla JE, Blevins TL, Grande-Allen KJ: Age-related structural changes in cardiac valves: implications for tissue engineered repairs. Am J Ger Cardiol, 15(5):311-5, 2006.
  • Allison DD, Grande-Allen KJ: Review. Hyaluronan: a powerful tissue engineering tool. Tissue Eng, 12(8):2131-40, 2006.
  • Brown EN, Peterson ML, Grande-Allen KJ: Biological systems and materials: a review of the field of biomechanics and the role of the Society for Experimental Mechanics, Exp Techniques, 30(2):21-30, 2006.
  • Grande-Allen KJ, Tissue engineering of heart valves, Biomedical Engineering Handbook, 3rd Edition, CRC Press: Boca Raton, FL, pp. 57-1 – 57-19, 2006.


  • Grande-Allen KJ, Barber JE, Klatka KM, Vesely I, Moravec CS, McCarthy PM: Mitral valve stiffening in end-stage heart failure: evidence of an organic contribution to functional mitral regurgitation. J Thorac Cardiovasc Surg, 130(3):783-790, 2005.
  • Grande-Allen KJ, Borowski A, Troughton R, Houghtaling P, DiPaola N, Moravec CS, Vesely I, Griffin BP: Apparently normal mitral valves in patients with heart failure demonstrate biochemical and structural derangements: an extracellular matrix and echocardiographic study. J Am Coll Cardiol, 45(1):54-61, 2005.


  • Grande-Allen KJ, Calabro A, Gupta V, Wight TN, Hascall VC, Vesely I: Glycosaminoglycans and proteoglycans in normal mitral valve leaflets and chordae: association with regions of tensile and compressive loading. Glycobiology, 14(7):621-633, 2004.
  • Allison DD, Drazba JA, Vesely I, Kader KN, Grande-Allen KJ: Cell viability mapping within long-term heart valve organ cultures. J Heart Valve Dis, 13(2):290-296, 2004.


  • Grande-Allen KJ, Mako WJ, Calabro A, Ratliff NB, Vesely I: Loss of chondroitin 6-sulfate and hyaluronan from failed porcine bioprosthetic valves. J Biomed Mater Res, 65A(2):251-259, 2003.
  • Setola V, Hufeisen SJ, Grande-Allen KJ, Vesely I, Glennon RA, Rothman RB, Roth BL: 3,4-methylenedioxymethamphetamine, (MDMA, “Ecstasy”) has fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro. Mol Pharmacol 63(6):1223-9, 2003.
  • Grande-Allen KJ, Griffin BP, Ratliff NB, Cosgrove DM, Vesely I: Glycosaminoglycan profiles of myxomatous mitral leaflets and chordae parallel the severity of mechanical alterations. J Am Coll Cardiol, 42(2):271-7, 2003.


  • Seidler DG, Breuer E, Grande-Allen KJ, Hascall VC, Kresse H: Core-protein dependence of epimerization on glucuronosyl residues in galactosaminoglycans. J Biol Chem 277(44):42409-42416, 2002.
  • Sedransk K, Grande-Allen KJ, Vesely I: Failure mechanics of mitral valve chordae tendineae. J Heart Valve Dis, 11(5):644-650, 2002.


  • Grande-Allen KJ, Cochran RP, Reinhall PG, Kunzelman KS: Mechanisms of aortic valve incompetence: finite element modeling of Marfan syndrome. J Thorac Cardiovasc Surg, 122(5):946-954, 2001.
  • Grande-Allen KJ, Griffin BP, Calabro A, Ratliff NB, Cosgrove DM III, Vesely I: Myxomatous mitral valve chordae II: Selective increase of glycosaminoglycans. J Heart Valve Dis, 10(3):325-333, 2001.
  • Grande-Allen KJ, Cochran RP, Reinhall PG, Kunzelman KS: Finite-element analysis of aortic valve-sparing: influence of graft shape and stiffness. IEEE Trans Biomed Eng, 48(6):647-659, 2001.
  • Grande-Allen KJ, Ratliff N, Griffin B, Cosgrove DM, Vesely I: Case report: Outer sheath rupture may initiate chordal rupture in fibrotic mitral valve disease. J Heart Valve Dis, 10(1);90-93, 2001.


  • Grande KJ, Cochran RP, Reinhall PG, Kunzelman KS: Mechanisms of aortic valve incompetence: finite element modeling of aortic root dilatation. Ann Thorac Surg, 69(6):1851-1857, 2000.
  • Grande-Allen KJ, Cochran RP, Reinhall PG, Kunzelman KS: Re-creation of sinuses is important for sparing the aortic valve. J Thorac Cardiovasc Surg, 119(4 Pt 1):753-63, 2000.
  • Grande KJ, Cochran RP, Reinhall PG, Kunzelman KS: Mechanisms of aortic valve incompetence in aging: finite element modeling. J Heart Valve Dis, 8(2):149-156,1999.
  • Grande KJ, Cochran RP, Reinhall PE, Kunzelman KD: Stress variations in the human aortic root and valve: the role of anatomic asymmetry. Ann Biomed Eng, 26(4):534-545, 1998.
  • Patwardhan AR, Evans JM, Berk M, Grande KJ, Knapp CF: Spectral indices of cardiovascular adaptations to short term simulated microgravity exposure. Integr Physiol Behav Sci, 30(3):201-214, 1995.
  • Kunzelman KS, Grande KJ, David TE, Cochran RP, Verrier ED: Aortic root and valve relationships: impact on surgical repair. J Thorac Cardiovasc Surg, 107(1):162-170, 1994.
  • Grande KJ, Kunzelman KS, Cochran RP, David TE, Verrier ED: Porcine aortic leaflet arrangement may contribute to clinical xenograft failure. ASAIO J, 39(4):918-922, 1993.