Dena Wiltz
B.S.E. Biomedical Engineering, Tulane University, 2007
Joined Spring 2009
Pursuing PhD in Bioengineering
Thesis: Determining characteristics of the aortic valve that lead to valve calcification
This research investigates the cellular and matrix components of calcified heart valves. In particular, it focuses on elucidating the characteristics of aortic valves that give rise to a propensity for calcification. This process entails an extensive look into cellular gene expression and calcified nodule formation. Calcified aortic valve disease (CAVD) involves hardening and narrowing of the valve, leading to improper blood flow, for which the only treatment is surgical valve replacement. Investigating these characteristics may pinpoint the ideal areas for engineering in an effort to prevent CAVD.